Top 10 Reasons For The Failure Of IVF | Why Does IVF Fail?

Unable to get pregnantIVF (In Vitro Fertilization) is a medical procedure that has helped millions of couples around the world to overcome infertility and successfully conceive a child. However, despite its high success rate, IVF can sometimes fail. Here are the top 10 reasons why IVF may fail:

1. Poor Egg Quality:

Poor egg quality is one of the most common reasons for IVF failure. As women age, the quality of their eggs decline, which can make it more difficult for the embryos to implant in the uterus. Poor egg quality can also result from underlying medical conditions, such as endometriosis or PCOS (Polycystic Ovary Syndrome).

2. Embryo Implantation Failure:

Even if the embryos are of good quality, they may not implant in the uterus properly. This can be due to a number of factors, such as the uterus being hostile to implantation or the embryo not being able to properly attach to the uterine lining. Sometimes, the embryo may not be able to develop into a blastocyst, which is necessary for successful implantation.

3. Chromosomal Abnormalities:

Chromosomal abnormalities can lead to implantation failure or miscarriage. As women age, the likelihood of chromosomal abnormalities in their eggs increases. In some cases, genetic testing of embryos (PGS or PGD) may be recommended to identify any chromosomal abnormalities before implantation.

4. Sperm Abnormalities:Poor sperm quality

The quality of the sperm used in IVF can also affect the success of the treatment. If the sperm are of poor quality or have low motility, they may not be able to fertilize the egg. Sometimes, there may be issues with sperm DNA fragmentation or the presence of anti-sperm antibodies.

Related- Does Sperm Quality Affect IVF Success?

5. Uterine Abnormalities:

Uterine abnormalities, such as fibroids or polyps, can interfere with implantation and lead to IVF failure. In some cases, a hysteroscopy may be recommended to identify any uterine abnormalities before undergoing IVF.

6. Lifestyle Factors:

Lifestyle factors, such as smoking, excessive alcohol consumption, and obesity, can also affect the success of IVF. These factors can have a negative impact on egg and sperm quality, as well as the overall health of the reproductive system.

7. Medication-Related Issues:

Certain medications used during IVF can also contribute to IVF failure, such as a poor response to ovarian stimulation medications. In some cases, a change in medication may be necessary to improve the chances of success.

8. Endometriosis:

Endometriosis is a medical condition in which the tissue that normally lines the inside of the uterus (called the endometrium) grows outside of the uterus. This misplaced tissue can grow on the ovaries, fallopian tubes, and other organs in the pelvic area, leading to pain, inflammation, and other symptoms. This can make it more difficult for the embryo to implant properly. Sometimes, surgery or other treatments may be recommended to treat endometriosis before undergoing IVF.

9. Immunological Factors:

Sometimes the body’s immune system can attack the embryos, leading to implantation failure. This can be due to a number of factors, such as autoimmune conditions or the presence of natural killer (NK) cells.

10. Unexplained Infertility:Unexplained Infertility

In some cases, IVF failure may be due to unexplained infertility, where no specific cause can be identified. However, further testing and evaluation may be necessary to identify any factors that may be contributing to infertility.

It is important to remember that IVF failure is not always due to the above reasons and can be due to a combination of factors. If you experience IVF failure, your doctor may recommend further testing or suggest alternative treatments. With careful evaluation and management, many couples are able to achieve success with IVF and start their journey toward parenthood at SRI IVF.


IVF failure can occur due to various factors, including age-related factors, embryo quality, genetic abnormalities, uterine factors, ovarian factors, male factors, lifestyle factors, implantation failure, technical factors, and immune factors. It is important for couples to understand these factors and work closely with their healthcare provider to identify the cause of IVF failure, and develop a personalized treatment plan.

For the past few years, SRI IVF has been effective in providing services for infertility with the best IVF treatment in Patiala. The fertility issues faced by couples have been overcome at SRI IVF. Do visit SRI IVF, if you are facing fertility issues.